HSD17B10 抗体
Quick Overview for HSD17B10 抗体 (ABIN498183)
抗原
See all HSD17B10 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of HADH2 protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity chromatography using epitope-specific immunogen
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纯度
- > 95 % (by SDS-PAGE)
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) antibody
HSD17B10 适用: 人, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5E2 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term) antibodyHSD17B10 适用: 人 WB, IF, ICC, IHC (p), IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 48-261) antibodyHSD17B10 适用: 人 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 48-261) antibodyHSD17B10 适用: 人, 小鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 1-261) antibodyHSD17B10 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 140-172) antibodyHSD17B10 适用: 人, 小鼠, 大鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB56913 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) antibodyHSD17B10 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 2-261) antibodyHSD17B10 适用: 人 WB, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 14-48) antibodyHSD17B10 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB56756 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 1-261) antibodyHSD17B10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))
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别名
- HSD17B10 / ERAB
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背景
- β-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer's disease. β-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of β-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated β-Amyloid-binding protein. ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer's disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to β-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that β-Amyloid induced cell death is mediated by ERAB.Synonyms: 17-beta-HSD10, 17-beta-hydroxysteroid dehydrogenase 10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, 3-hydroxyacyl-CoA dehydrogenase type-2, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, HADH2, MRPP2, Mitochondrial Marker, Mitochondrial ribonuclease P protein 2, SCHAD, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, XH98G2
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分子量
- approx. 27 kDa
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基因ID
- 3028
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NCBI登录号
- NP_001032900
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UniProt
- Q99714
抗原
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